WebJun 3, 2024 · Bacterial lipoproteins are secreted proteins that are post-translationally lipidated. Following synthesis, preprolipoproteins are transported through the cytoplasmic membrane via the Sec or Tat translocon. As they exit the transport machinery, they are recognized by a phosphatidylglycerol::prolipoprotein diacylglyceryl transferase (Lgt), … WebOct 14, 2008 · Introduction: To clarify the role that prolipoprotein diacylglyceryl transferase (Lgt) and lipoprotein‐specific signal peptidase II (LspA) play in the physiological function of MsmE, we constructed lgt ‐deficient and lspA ‐deficient mutants of Streptococcus mutans 109c and examined the potential role of Lgt and LspA in membrane anchoring and …
Purification and characterization of diacylglycerol …
WebJun 29, 2024 · The unique and ubiquitous bacterial lipoprotein biosynthesis pathway is an attractive new antibiotic target. Crystal structures of its three biosynthetic enzymes have been solved recently. The first enzyme, Phosphatidylglycerol:proLipoprotein diacylglyceryl Transferase (Lgt), which initiates the post-translational modification at the metabolic … WebThe structure-function relationship of bacterial prolipoprotein diacylgyceryl transferase (LGT) Has been investigated by a comparison of the primary structures of this enzyme in phylogenetically distant bacterial species, analysis of the sequences of mutant enzymes, and specific chemical modification of the Escherichia coli enzyme. onslow village cafe
ENZYME - 2.5.1.145 phosphatidylglycerol--prolipoprotein …
WebMay 30, 2024 · PhD Chemistry. 2024 - 2024. BBSRC Industrial CASE Award under supervision of Professor Jon Essex and industrial partner UCB, developing a protocol for enhanced sampling simulation of antibodies. The methods were then applied to a live project during an internship at UCB. Presented PhD work at the following conferences: - Poster … Webtransferase. The following hypothetical proteins were matched from the other species as indicated (percent similarity in parentheses after gene ... 98 1164 outer membrane prt P5 (ompA) 96 0904 prolipoprotein diacylglyceryl Tase (Igt) 80 0030 rare Ipp A (rlpA) 58 0922 rare IppB (rlpB) 62 Murein sacculus and peptidoglycan 1140 DAla-D-Ala ligase ... onslow village church