Hif-1 alpha protein

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August undefined, 2024

Web3 de jul. de 2003 · Endothelial PAS domain-containing protein 1. Gene. EPAS1. Status. UniProtKB reviewed (Swiss-Prot) Organism. Homo sapiens (Human) Amino acids. 870. Protein existence. Evidence at protein ... Hypoxia-inducible factor 2-alpha (HIF-2-alpha; HIF2-alpha) Member of PAS protein 2; PAS domain-containing protein 2; Gene names. … WebCommon gene targets for HIF-1 and HIF-2 include VEGFA and GLUT1 (5). The HIF-2 alpha subunit is rapidly targeted and degraded by the ubiquitin proteasome system under normoxic conditions. This process is mediated by oxygen-sensing enzymes, prolyl hydroxylase domain enzymes (PHDs), which catalyze the hydroxylation of key proline …

HIF-1 alpha protein as a target for S-nitrosation - PubMed

Web21 de mar. de 2024 · HIF1A (Hypoxia Inducible Factor 1 Subunit Alpha) is a Protein Coding gene. Diseases associated with HIF1A include Retinal Ischemia and Enchondromatosis, Multiple, Ollier Type.Among its related pathways are Signaling by PTK6 and Regulation of activated PAK-2p34 by proteasome mediated degradation.Gene … WebThe mTOR and HIF-1 alpha protein decreased about five folds while the VEGF decreased about three folds compared with control and NC groups (P<0.05). Figure 2 Vandetanib … iowa realty companies

Hypoxia-inducible factor 1-alpha (human) Protein Target

WebNational Center for Biotechnology Information Web3 de abr. de 2024 · This gene encodes the alpha subunit of transcription factor hypoxia-inducible factor-1 (HIF-1), which is a heterodimer composed of an alpha and a beta … WebHIF-1 is a heterodimer formed by the association of a constitutively expressed HIF-1 beta subunit and a HIF-1 alpha subunit, the expression of which is highly regulated. In this study, pharmacologic concentrations of melatonin was found to inhibit expression of HIF-1 alpha protein under both normoxic and hypoxic conditions in DU145, PC-3, and LNCaP … open dated cheque

HIF1A Gene - GeneCards HIF1A Protein HIF1A Antibody

HIF1A - Wikipedia

WebDescription. HIF1A Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 298 amino acids (530-826) and having a molecular mass of … Web10 de dez. de 2009 · Hypoxia-inducible factor 1 alpha (HIF-1α) and vascular endothelial growth factor (VEGF) are frequently overexpressed in numerous types of cancers and are known to be important regulators of angiogenesis. Until now, few studies have been carried out to investigate the prognostic role of these factors in solid tumors, especially in … iowa realty coralvilleWebHIF1-alpha (HIF1A) is a subunit of HIF1, which is a transcription factor found in mammalian cells cultured under reduced oxygen tension. HIF-1 is a heterodimer consisting of an alpha and beta subunit, both belonging to the basic-helix-loop-helix Per-aryl hydrocarbon receptor nuclear translocator-Sim (PAS) family of transcription factors. iowa realty connect

"Web5 de set. de 1997 · Findings strongly suggest that the hypoxia induced changes in HIF-1alpha stability and subsequent gene activation are mediated by redox-induced changes. The hypoxia-inducible factor 1 transcriptional activator complex (HIF-1) is involved in the activation of the erythropoietin and several other hypoxia-responsive genes. The HIF-1 … " - Hif-1 alpha protein

Hif-1 alpha protein

HIF-1 alpha detection in WB protocol Abcam

WebCommon gene targets for HIF-1 and HIF-2 include VEGFA and GLUT1 (5). The HIF-2 alpha subunit is rapidly targeted and degraded by the ubiquitin proteasome system under … WebHIF1A es un factor de transcripción con dominios HLH - PAS encontrado en células de mamíferos que crecen en concentraciones bajas de oxígeno. Juega un papel esencial en la respuesta celular y sistémica a la hipoxia. 5 HIF1A es una de las clases de factores inducibles por hipoxia, una familia que incluye HIF1A, HIF2A y HIF3A .

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WebProtein function. HIF-1 alpha functions as a master transcriptional regulator of the adaptive response to hypoxia; Under hypoxic conditions, it can activate over 40 genes, whose protein products increase oxygen delivery or facilitate … Web4 de abr. de 2024 · HIF-1a_CTAD; HIF-1 alpha C terminal transactivation domain cd19727 Location: 13 → 83 bHLH-PAS_HIF1a_PASD8; basic helix-loop-helix-Per-ARNT-Sim (bHLH-PAS) domain found in hypoxia-inducible factor 1-alpha (HIF1a) and similar proteins; XM_006515478.4 → XP_006515541.1 hypoxia-inducible factor 1-alpha isoform X2. …

Web9 de dez. de 2014 · HIF-1 alpha contained in a nuclear extract, binds specifically to the HIF-1 alpha response element. The HIF transcription factor complex is detected by addition of a specific primary antibody directed against HIF-1 alpha. A secondary antibody conjugated to HRP is added to provide a sensitive colorimetric readout at 450 nm. Web9 de abr. de 2024 · To answer to these questions, we treated epithelial HaCaT and breast cancer MCF-7 cells with different ZnO-NR concentrations. Our results showed that ZnO-NR treatments increased cell death through ROS accumulation, HIF-1α and endothelial PAS domain protein 1 (EPAS1) activation, and induction of autophagy and mitophagy in both …

WebProtein target information for Hypoxia-inducible factor 1-alpha (human). Find diseases associated with this biological target and compounds tested against it in bioassay … WebThis antibody does not cross-react with ARNT or the related HIF-2 alpha. MA1-516 has been successfully used in Western blot, immunofluorescence, immunoprecipitation, immunocytochemistry, and gel shift procedures. By Western blot, this antibody detects an ∽116 kDa protein representing HIF-1 alpha after hypoxic induction in COS cells.

WebInduction of HIF-1 alpha by CoCl 2 (cobalt chloride) Grow your cells of choice to 70–80% confluency in the appropriate culture media. Immediately prior to use, prepare a 100 mM CoCl 2 stock solution in PBS. Add 100–150 µM CoCl 2 final solution directly to cell culture media. Mix well.

Web21 de mar. de 2024 · HIF1A (Hypoxia Inducible Factor 1 Subunit Alpha) is a Protein Coding gene. Diseases associated with HIF1A include Retinal Ischemia and Enchondromatosis, … iowa realty corporate officeWebUnder hypoxic conditions, activates the transcription of over 40 genes, including erythropoietin, glucose transporters, glycolytic enzymes, vascular endothelial growth factor, HILPDA, and other genes whose protein products increase oxygen delivery or facilitate … Induces stabilization of the protein. 1 publication. Sequence: S → A: … We'd like to inform you that we have updated our Privacy Notice to comply … UniRef - UniProt History - UniProt External Links - UniProt Gostaríamos de exibir a descriçãoaqui, mas o site que você está não nos permite. Induces stabilization of the protein. 1 publication. Sequence: S → A: … YTH domain-containing protein 1 · Gene: YTHDC1 (KIAA1966, YT521) · Homo … iowa realty corporateWeb21 de mar. de 2024 · The protein encoded by this gene catalyzes the post-translational formation of 4-hydroxyproline in hypoxia-inducible factor (HIF) alpha proteins. HIF is a transcriptional complex that plays a central role in mammalian oxygen homeostasis. This protein functions as a cellular oxygen sensor, and under normal oxygen concentration, … iowa realty creston iowaWeb1 mg/mL: Formule: PBS with 0.05% sodium azide: Numéro d’ordre du gène: Q16665, Q61221, O35800: Symboles de gène(s) HIF1A: Immunogène: A fusion protein including residues 530-825 of the mouse HIF-1 alpha protein. Quantité: 100 μL: Primaire ou secondaire: Primary: Espèces cibles: Rat, Rabbit, Non-human Primate, Mouse, Human ... iowa realty decorah iaWeb30 de jan. de 2003 · HIF-1 alpha stability regulation initiates a complex biological response that allows cells to act appropriately to meet patho-physiological situations of decreased … iowa realty davenportWebThis gene encodes the alpha subunit of transcription factor hypoxia-inducible factor-1 (HIF-1), which is a heterodimer c omposed of an alpha and a beta subunit. HIF-1 functions as … open datepicker when click on input fieldWeb12 de abr. de 2024 · Scientific Reports - MicroRNA-142-3p promotes renal cell carcinoma progression by targeting RhoBTB3 to regulate HIF-1 signaling and GGT/GSH pathways Skip to main content Thank you for visiting ... open date airline tickets